Manganese-Catalyzed Oxidative Cross-Coupling Reactions

3 Manganese-Catalyzed Oxidative Cross-Coupling Reactions 

Several examples of the oxidative homo-couphng of alkynyl Grignard reagents are described in the hterature. By contrast, there is only one example of an oxidative 

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Sequential cross-coupling reactions of 2,4-dichloropurine 69 have been conducted. 2,6-Disubstituted purine 69 was cross-coupled with MeZnBr to give monosubstituted purine 70, which underwent Suzuki cross-coupling with phenylboronic acid to furnish disubstituted purine 71. Recently, the synthesis of 6-(2-hydroxyethyl)purines was developed based on the Negishi palladium-catalyzed cross-coupling reactions of 6-chloropurines with the Reformatsky reagent followed by reduction by sodium borohydride and treatment with manganese(IV) oxide. ... 

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