Malarial parasites glucose

Roth E Jr, Joulin V, Miwa S et al (1988) The use of enzymopathic human red cells in the study of malarial parasite glucose metabolism. Blood 71(5) 1408-1413... 

Finally, perhaps an explanation for the beneficial effects of coenzyme A (CoA), malate and pyruvate for the extracellular in vitro growth of P. lophurae found by Trager (1952) and interpreted by Moulder (1962) to neatly explain the shift in pattern of carbohydrate metabolism accompanying liberation of parasites from the host cell. .. (The) lack of CoA in free parasites logically explains the lessened rate of pyruvic acid oxidation via the Krebs cycle. It is difficult to escape the conclusion that the inability of plasmodia to synthesize CoA extracellularly results in extensive dislocations in glucose metabolism, which in turn contribute heavily to the restriction of the malarial parasite to an intracellular habitat is this malate and pyruvate could be linked to the generation of dihydronicotinamide adenine dinucleotide (NADH) for glycolysis, and a CoA deficiency could limit activity in pathways other than the TCA cycle. 

Bovamick, M., Lindsay, A., and Hellerman, L. (1946). Metabolism of the malarial parasite, with reference particularly to the action of antimalarial agents. II. Atabrine (quinacrine) inhibition of glucose oxidation in parasites initially depleted of substrate. Reversal by adenylic add.. Biol. Chem. 163,535-551. 

Hempelmann, E., and Wilson, R. J. (1981). Detection of glucose-6-phosphate dehydrogenase in malarial parasites. Mol. Biochem. Parasitol. 2,197-204. 

The schizont stage of the malarial parasite utilizes the Mayerhof sequence efficiently to convert glucose to lactic acid. In Entamoeba histolytica the major pathway of glucose utilization is the formation of pyruvate from... 

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