Malaria prophylactic regimens

In addition, sulfadoxine and pyrimethamine (Fansidar) are indicated in prophylaxis of malaria in individuals traveling to areas where chloroquine-resistant P. falciparum malaria is endemic. However, resistant strains may be encountered. Regardless of the prophylactic regimen used, it is still possible to contract malaria. Moreover, this combination has been used as a prophylactic agent in the prevention of Pneumocystis carinii pneumonia in patients with AIDS. 

Quinacrine and its congeners display substantia] activity against the asexual erythrocytic forms of plasmodia that cause human malaria, but they are neither causally prophylactic nor radically curative and have no action on the gametocytes. The acridines are therefore used for suppressive therapy and they resemble the 4-aminoquinolines and quinine in this respect quinacrine is less toxic and more elfective than quinine but more toxic and less effective than chloroquine. The recommended regimen for quinacrine to terminate acute malarial attacks is 2800 mg given over seven days, with initial administration of five loading doses of 200 mg every six hours to... 

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