Major histocompatibility complex antigen binding affinity

Kumar, V., Bhardwaj, V., Soares, L., Alexander, J., Sette, A. and Sercaz, E. (1995) Major histocompatibility complex binding affinity of an antigenic determinant is crucial for the differential secretion of interleukin 4/5 or interferon-y by T cells. Proceedings of the National Academy of Sciences USA 92, 9510-9514. 

The staphylococcal superantigens initially bind to conserved elements on major histocompatibility complex class II molecules with relatively high affinity (A(i 10 mol 1 ). These receptors are found in abundance, throughout the body, on antigen-presenting cells such as macrophages and monocytes. However, each toxin... 

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