Major drug-metabolizing cytochromes humans

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Constitutive e3q>ression and localization of the major drug metabolizing enzyme, cytochrome P4502D in human brain. Brain Res Mol Brain Res 103 49-61. 

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McGinnity DF, Parker AJ, Soars M, Riley RJ (2000) Automated definition of the enzymology of drug oxidation by the major human drug metabolizing cytochrome P450s. Drug Metab Dispos 28 1327-1334... 

McGinnity, D.F. Griffin, S.J. Moody, G.C. Voice, M. Hanlon, S. Friedberg, T. Riley, R.J. Rapid Characterization of the Major Drug-metabolizing Human Hepatic Cytochrome P-450 Enzymes Expressed in Escherichia coli, Drug Metab. Dispo. 27(9), 1017-1023 (1999). 

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The enzymes of the cytochrome P 4503A family are the predominant phase I drug metabolizing enzymes in man. The major isoform of the CYP3A family is CYP3A4, the predominant form found in adult human liver and small intestine. Members of the 3A4 family are estimated to be responsible for the metabolism of more than one half of all drugs that are substrates... 

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