Magnetic Resonance Imaging overview

TWo excellent overviews of fluonne NMR in biochemistry have been published [208, 209] The diverse studies can be organized by compound type or applica tion Applications include detection oforganofluorine compounds in human plasma [210] and magnetic resonance imaging (MRI) of fluonne compounds (discussed below) 19F-NMR spectroscopy has been used to follow the metabolic fates of fluonnated compounds such as fluoroamlmes [211, 212], tnfluoromethylamhnes [213], fluoroacetates [214], chain-fluonnated polyamines [85], fluorodeoxyglu-cose [275], and 5 -deoxy-5-fluoroundine [2/61... 

Kanal, E., 1992, An overview of electromagn c safety considerations associated with magnetic resonance imaging, Annals of the New York Academy cf Sciences, 649 204-224. 

Laser-induced fluorescence (LIF) has also been utilized as a highly sensitive detection principle for CE [48-51]. However, while the LIF detector is now able to achieve zeptomole (10 21) detection limits, conventional derivatization techniques are inefficient at these exceptional levels [52]. Also, CE has successfully been coupled with mass spectrometry (MS) [53], nuclear magnetic resonance (NMR) [54, 55], near-infrared fluorescence (NIRF) [56, 57], radiometric [58], flame photometric [59], absorption imaging [60], and electrochemical (conductivity, amperometric, and potentiometry) [61-63] detectors. A general overview of the main detection methods is shown is Table 1 [64]. 

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