Magnesium therapy intravenous

Schuh S, Maklas C, Freedman SB, Flint AC, Zork JJ, Bajaj L, Black KJ, Johnson DW, Boutis K North American practice patterns of intravenous magnesium therapy in severe acute asthma in children. Acad Emerg Med 2010 17(11) 1189-96. 

Sullivan JT, Higgins N, Toledo P, Scavone BM, McCarthy RJ, Wong CA. The effect of intravenous magnesium therapy on the duration of intrathecal fentanyl labor analgesia. Int J Obstet Anesth 2012 21(3) 212-6. 

L A. Nephrotoxicity is the most common and most serious toxicity associated with amphotericin B administration. This is manifested by azotemia (elevated serum blood urea nitrogen and creatinine), and by renal tubular acidosis, which results in the wasting of potassium and magnesium in the urine (leading to hypokalemia and hypomagnesemia, requiring oral or intravenous replacement therapy). Normochromic normocytic anemia is also seen with long-term amphotericin B administration. Elevation of hver enzymes is not associated with the use of amphotericin B. 

Acetylsalicylic acid is usually given by oral administration (0.5-8 g/day) for pain and inflammation and for antiplatelet therapy (75-100 mg/day). It is also available in rectal and topical formulations and as a soluble lysine derivative for intravenous or intramuscular application. Acetylsalicylic acid is often used in multi-drug preparations. The main side-effects are gastrointestinal disorders. Use in children is limited due to the risk of Reye s syndrome (Waldmann et al., 1982). The lithium, magnesium, calcium, and aluminium salts of acetylsalicylic acid are used in some special preparations. 

Severe hyperkalemia has been reported in pregnant intravenous drug abusers during prolonged parenteral magnesium sulfate therapy for treatment of toxemia (8). Hypermagnesemia was thought to be responsible. 

Urinary potassium and magnesium losses are anticipated consequences of AmB therapy. Some of the losses can be compensated for with increased dietary intake, while others will require oral or intravenous replacement. It should be recognized that the serum levels of these ions do not necessarily correlate with the total deficit, as the plasma levels tend to be conserved while cellular stores are becoming depleted. In general, potassium and magnesium supplements should be given to all patients and the amounts increased if the... 

In therapy, magnesium is used either intravenously or as an oral supplement. Intravenous magnesium is the treatment of choice for pathophysiological conditions such as torsade de points or eclampsia (lan-nello and Belfiore 2001). In a randomized, placebo-controlled trial in more than 10000 pre-eclamptic pregnant women, magne-... 

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