Monoperphthalate, magnesium

Magnesium monoperphthalate (MMPP, 1). Suppliers Aldrich, Interox Chemicals Ltd. 

H. Heaney, Oxidation Reactions Using Magnesium Monoperphthalate and Urea Hydrogen Peroxide, Aldrichimica Acta 1993, 26, 35 15. 

Pure MCPBA is shock sensitive and can deflagrate. Magnesium monoperphthalate is not shock sensitive and does not deflagrate. MMPP is cheaper than MCPBA and loses available oxygen at a slower rate than MCPBA. The reagent is water soluble and hence epoxidations are carried out in a water-4sopro-panol mixture. Epoxidation of cyclohexene with MMPP in isopropanol- ater at 25 C for 7 h furnishes the epoxidation [ oduct in 85% yield. ... 

Oxidation of cyclic imines 328 with magnesium monoperphthalate (MMPP) in methanol afforded oxaziridines 329 and 330 in good to excellent yields as a mixture of diastereomers (Table 25) <2003JME2397>. This oxidizing system has also been employed in the synthesis of other cyclic oxaziridines <1998TL5853>. 

Brougham, P Cooper, M. S., Cummerson, D. A., Heaney, H., Thompson, N. Oxidation reactions using magnesium monoperphthalate a comparison with m-chioroperoxybenzoic acid. Synthesis 1987, 1015-1017. 

Outside of the category of manganese porphyrins, one report indicates nuclease activity of a Schiff base manganese complex [Mn (salen)] when activated by magnesium monoperphthalate. Singlestrand breaks are observed at micromolar concentrations of the complex 163). 

Human immunodeficiency virus Hematoporph3uin 5-Methylene-2(5H)-furanone Magnesium monoperphthalate... 

The choice of the oxidant is primordial, as it acts both as the nucleophile and the leaving group. A reactivity order of oxidants has been established [174]. Peracids and especially m-CPBA [296] are the most efficient oxidants for the Baeyer-Villiger reaction, followed by alkyl peroxides. The reaction with peracids proceeds faster under acid catalysis [297], but buffered solutions can also be used. Some ketones are un-reactive under standard conditions, and need to be transformed into their hemiketals [298]. Safer peracids such as MMPP (magnesium monoperphthalate) [299, 300] and sodium perborate [301] have also been applied giving similar results as m-CPBA. Recently, processes with solid-supported peracids [302] and transformations in the solid state [303] have been developed. 

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