Solid-state NMR magic angle spinning

High-Resolution Magic Angle Spinning and Cross-Polarization Magic Angle Spinning Solid-State NMR Spectroscopy... 

In this review we shall emphasize some of the unique features of HREM and, in so doing, illustrate how, in association with one or other of the additional techniques mentioned above, or in association with separate studies (e.g. magic-angle-spinning solid-state NMR), HREM has clarified several new, or hitherto enigmatic, features of the chemistry of inorganic solids. In particular we discuss, how ... 

R. Verel. Adiabatic methods for Homonuclear Dipolar Recoupling in Magic Angle Spinning Solid-State NMR. PhD thesis, ETH Zurich, Diss. Nr. 14152, 2001. 

Abstract Membrane proteins represent an important and challenging frontier in structural biology they mediate fundamental and medically important processes but are challenging targets for structure/ function studies. Magic angle spinning solid-state NMR methods for structure determination of proteins have developed rapidly in... 

M. H. Levitt, Symmetry-based pulse sequences in magic-angle spinning solid-state NMR. in Encyclopedia of Nuclear Magnetic Resonance, D. M. Grant and R. K. Harris (eds.), Supplementary Volume, Wiley, Chichester, 2002, pp. 165-196. 

Solid-state NMR also can be applied to membrane proteins in lipid bilayers, and recent advancements in magic angle spinning solid-state NMR show promise for stmcture determination. Although the stmctures of small crystalline proteins (89) and membrane bound peptides (90) have been determined, the stmcture of a polytopic membrane protein has yet to be reported. The major necessity that is required to push the technique forward is the de novo sequential chemical shift assignment of the amino acid residues, and in the last few years, several groups have reported successful strategies (91, 92). 

R. Verel, M. Baldus, M. Nijman, J. W. M. van Os and B. H. Meier, Adiabatic homonuclear polarization transfer in magic-angle-spinning solid-state NMR. Chem. Phys. Lett., 1997, 280. 31-39. 

Si04 tetrahedra. These silica structures have been determined mainly by X-ray and neutron diffraction methods and, more recently, by Si and A1 magic angle spinning solid-state NMR studies. 

McDermott A (2009) Structure and dynamics of membrane proteins by magic angle spinning solid-state NMR. Ann Rev Biophys 38 385 03... 

Kijac AZ, Li Y, Siigar SG, Rienstra CM (2007) Magic-angle spinning solid-state NMR spectroscopy of nanodisc-embedded human CYP3A4. Biochemistry 46 13696-13703... 

Detken A, Hardy EH, Ernst M et al (2002) Simple and efficient decoupling in magic-angle spinning solid-state NMR. The XiX scheme. Chem Phys Lett 356 298-304... 

Hehnus JJ, Nadaud PS, Hofer N et al (2008) Determination of methyl [sup 13]C-[sup 15]N dipolar couplings in peptides and proteins by three-dimensional and four-dimensional magic-angle spinning solid-state NMR spectroscopy. J Chem Phys 128 052314... 

Franks WT, Zhou DH, Wylie BJ et al (2005) Magic-angle spinning solid-state NMR spectroscopy of the pi immunoglobulin binding domain of protein G (GBl) N and C chemical shift assignments and conformational analysis. J Am Chem Soc 127 12291-12305... 

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