Magic-angle spinning organic solids

R. Warrass and G. Lippens, Quantitative monitoring of solid phase organic reactions by high-resolution magic angle spinning NMR spectroscopy,./. Org. Chem., 2000, 65, 2946-2950. 

Solid-state NMR with magic angle spinning has been used to good effect in studying organic crystals and their dynamics [41]. The powdered samples used in such studies can stabilize reaction intermediates or products and provide them with a uniform molecular environment. In order to simplify the spectra, this technique intentionally discards the information contained in... 

Correlating positively with the hydrophobicity of the solvent, different fractions of inactivated active centers were measured in different solvents with solid-state NMR spectroscopy (13C-cross-polarization/magic angle spinning (MAS) NMR) (Burke, 1992). Just as with tritiated water (see above), immediate desorption of water molecules from the protein surface was observed after addition to the organic solvent. 

Tris(hydroximato) germanium compounds have been successfully characterized by the solid-state 13C and 1SN variable-amplitude cross-polarization/magic angle spinning (VACP/MAS) NMR approach because of their low solubility in organic solvents <2002IC3901>. 

Rousselot-Pailley, P., Ede, N.J., Lippens, G. Monitoring of solid-phase organic synthesis on macroscopic supports by high-resolution magic angle spinning NMR J. Comb. Chem., 2001, 3 (6), 559-563... 

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