Maddox Wing Test

Verapamil. After taking verapamil 80 mg three times daily for 2 days, 9 healthy female subjects were given midazolam 15 mg orally. The AUC of the midazolam was increased threefold, the maximum serum levels were doubled, and the half-life increased by 41%. It was almost impossible for the subjects to stay awake for 90 minutes after taking the midazolam. They suffered several hours of amnesia and there was a marked decrease in the performance of pharmacodynamic tests (digit symbol substitution, Maddox wing test). ... 

A pharmaeokinetie study in 10 healthy subjects found that rifampicin 600 mg daily for 5 days reduced the AUC of a single 15-mg oral dose of midazolam by 96%, and reduced the half-life by almost two-thirds. The psychomotor effects of the midazolam (as measured by the digit symbol substitution test, Maddox wing test, postural sway and drowsiness) were almost totally lost. ... 

A study in 12 healthy subjects found that both sublingual buprenorphine 400 micrograms and oral amitriptyline 50 mg impaired the performanee of a number of psychomotor tests (digit symbol substitution, flicker fusion, Maddox wing, hand-to-eye coordination, reactive skills), and the subjects felt drowsy, feeble, mentally slow and muzzy. When amitriptyline 30 mg, increased to 75 mg daily was given for 4 days before a single dose of buprenorphine, the psychomotor effects were not significantly increased, but the respiratory depressant effects of the buprenorphine were enhanced. ... 

Triazolam 500 micrograms orally was given to 10 healthy subjects before and after rifampicin 600 mg daily or a placebo for 5 days. Rifampicin reduced the triazolam AUC by 95% and decreased the maximum plasma triazolam levels by 88% when compared with the placebo group. The elimination half-life was reduced from 2.8 to 1.3 hours. Pharmacodynamic tests (drowsiness, sway, Maddox wing, etc.) showed that rifampicin abolished the effects of triazolam. ... 

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