Macrolides and Their Constituent Segments

Reagents i, TbdmsCI ii. NaH, DMF iii, MegCuLi iv, PhSH, TsOH v, PhCH(0Me)2. mol. sieves vi, TbdmsOTf, 2.6-lutidine vii. mCPBA, CH2CI2 viii, 82. LDA, then 83, then U naphthalenide, then MeOH 

The aglycone of. rosaramycin is identical in its eastern half with tylonolide (32). An intermediate (35) representing C-2 to 

A number of glucose-derived compounds have been reported which 

The total synthesis of the 16-membered macrodiolide elaiophilin has been accomplished by a route which involved as a key step the reaction of a boron enolate of (47), derived from glucose (numbers 

A synthesis of avermectin has been achieved using the previously reported (S.Hanessian, A. Ugolini, and M. Therein, 

L-lsoleucine. A full account has been given of the synthesis of the spiroketal antibiotic A23187 (calcimycin) from glucose (see Vol. 18, p.250-1). Full details have also been reported for the synthesis of a glucose-derived fragment, mentioned last year (Vol. 19, p.256), corresponding to C(9)- C(14) of okadaic acid, and the total synthesis of the complete structure of this marine toxin has 

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Macrolides, Macrocyclic Lactams and Their Constituent Segments... 

Macrolides, Macrocyclic Lactams, and their Constituent Segments 355... 

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