Synthesis, macrocyclic kinase inhibitors

Macrocyclic phosphonates have been reported as kinase inhibitors (P12WO074951). In a representative synthesis, 4-chloropyrimidine 31 was reacted with the aminoisoindolone 32 leading to the 2,4-diaminopyrimidine 33 in 79% yield (Scheme 7). Selective monodeprotection of phosphonate followed by coupling using PyBOP in h h dilution conditions afforded... 

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