Macrocyclic Hsp90 inhibitors geldanamycin

In this section, apart from a very short historical introduction, the use of genetic modifications to biosynthetic pathways to biochemically produce and identify macrocyclic molecules that have Hsp90 binding activity, giving structures that have not yet been approached synthetically, will be presented. A much fuller story of the discoveries that led to the clinical development of a number of macrocyclic compounds as Hsp90 inhibitors using the basic geldanamycin skeleton will be presented in Chapter 2. It should be noted... 

---