Macrocycles and oligopyrroles

3-sulfolenoporphyrins 05TL2009 . The introduction of trimethylammonium groups 05JPP290 , cationic peptides 05CC4652 , and cobaltacarboranes 05CC1306 onto meso-substituents was disclosed. 

A class of novel sulfur-bridge pyrrole macrocycles was discovered 05CC2122 . For example, treatment of dipyrromethane 85 with disulfur dichloride led to the formation of disulfide linked tetrapyrrole 86. 

Synthetic approaches to a,a-linked quater-, penta-, and sexipyrroles (i.e., 87) have been developed starting from bip3rrole and trip3rrole intermediates 05OL1887 . This compounds could prove useful in the preparation of novel expanded porphyrins. 

The synthesis and biological evaluation of pyrrole macrocycles (i.e., porphyrins, expanded porphyrins, and calixpyrroles) and linear oligopyrroles comprise perhaps the largest body of work published each year that can be classified as pyrrole chemistry. Unfortunately, due to space limitations, the discussion of selected advances in this area could not be included. 

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