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Macralstonine acetate

Three dimeric alkaloids from Alstonia angusHfoHa, macrocarpamine (293), macralstonine acetate and villalstonine (289) possess significant in vitro activity against Entamoeba histolytica and Plasmodium falciparum, protozoans causing amoebic dysentery and cerebral malaria, respectively [211]. The EDso/gM of the compounds against . histolytica were macrocarpamine... [Pg.416]

The bisindole alkaloids macrocarpamine (323), macralstonine acetate (semisynthetic), and villalstonine (322) from A. angustifolia were found to possess significant in vitro antiamoebic activity against E. histolytica and P. falciparum, but were 4-8 times less potent than emetine against E. histolytica, and 15-50 times less potent than chloroquine against P. falciparum (240). Villalstonine and macrocarpamine were... [Pg.239]

See other pages where Macralstonine acetate is mentioned: [Pg.417]    [Pg.417]    [Pg.324]    [Pg.230]   
See also in sourсe #XX -- [ Pg.416 ]



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Macralstonine

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