Maclura pomifera lectin

Hemagglutination Inhibition of Crude Maclura pomifera Lectin by Simple Sugars835... 

Table XIII shows the potency with which AFGP inhibited hemagglutination by Osage orange (Maclura pomifera) lectin. At a final concentration in the reaction mixtures of less than 1 /xg/ml, the active AFGP completely inhibited hemagglutination of both human group-0 and sheep erythrocytes. By contrast, the inactive AFGP component was some 50-100 times less active as an inhibitor. Several other randomly tested preparations containing glycoproteins of diverse origin were either inactive or comparatively weak inhibitors.

A few investigators have studied the appearance and disappearance of lectins during the life cycle of the plant.242,243 J. M. Jones and coworkers242 reported that Maclura pomifera agglutinin begins to accumulate... 

The active AFGP 1-5 were first reported by Chuba and co-workers (1973) to inhibit hemagglutination by a lectin prepared from the seeds of the Osage orange (Maclura pomifera). Although the structural requirements for the antilectin activity closely parallel those for antifreeze activity, these two activities appear to be unrelated, with the probable exception that they both require considerable integrity of the carbohydrate side chain and polymeric size. 

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