M-Dihydroxy benzene

It is a lipophilic compound which removes intercellular lipids that are covalently linked to the cornified envelope surrounding epithelial cells [3]. It also enhances penetration of other agents. Resorcinol (m-dihydroxy benzene) is structurally and chemically similar to phenol. It disrupts the weak hydrogen bonds of keratin [4]. Lactic acid is an alpha hydroxy acid which causes corneocyte detachment and subsequent desquamation of the stratum corneum [5]. 

An amino group on the benzene ring is directly hydrolyzable only when it is in the meta position to hydroxyl or other amino groups. m-Dihydroxy-benzene (resorcinol) has been made by the Bucherer reaction, and 1,3,5 trihydroxybenzene (phloroglucinol) is obtained by direct hydrolysis and decarboxylation of 2,4,6-triaminobenzoic acid. ... 

Water-m-dihydroxy-benzene (resorcinol) in the range of 0.1 to 10.0 M concentration gives the following relationship ... 

Nylon 12 (PA 12) Nylon 612 (PA 612) Marlon 8 8 Nylon 66 (PA 66) Polyamide Polyamide, Nylon MXD6 (PA MXD6) Polycarbonate Polyethylene, HDPE Polymethyl Methacrylate (PMMA) m-Dihydroxy benzene 0 0 0 Polyamide, Nylon 6, Copolymer Polyamide, Nylon 6, Modified Polyamide, Nylon, Modified 7 7 7... 

Ro = initial reaction rate of dihydroxy benzene formation (mol/m s). 

Mandado, M. Grafla, A. M. Mosquera, R. A. Do 1,2-ethanediol and 1,2-dihydroxy-benzene present intramolecular hydrogen bond , Phys. Chem. Chem. Phys. 2004, 4391-4396. 

The influence of substituents on the solubility of molecules in water can be due to their effect on the properties of the solid or liquid (for example, on its molecular cohesion) or to the effect of the substituent on its interaction with water molecules. It is not easy to predict what effect a particular substituent will have on crystal properties, but as a guide to the solvent interactions, substituents can be classified as either hydrophobic or hydrophilic, depending on their polarity (see Table 5.4). The position of the substituent on the molecule can influence its effect, however. This can be seen in the aqueous solubilities of o-, m- and p-dihydroxy-benzenes as expected, all are much greater than that of benzene, but they are not the same, being 4, 9 and 0.6 mol dm, respectively. The relatively low solubility of the para compound is due to the greater stability of its crystalline state. The melting points of the derivatives indicate that is so, as they are 105°C, 111°C, and IZO C, respectively. In the case of the ortho... 

McBride, M.B. 1989b. Oxidation of 1,2- and 1,4-dihydroxy benzene by birnessite in acidic aqueous suspension. Clays Clay Miner. 37 479-486. 

Synonyms m-hydroxyphenol 3-hydroxy-phenol 1,3-benzenediol 1,3-dihydroxy-benzene m-dihydroxybenzene resorcin... 

Synonyms 1,3-Benzenediol m-Benzenediol Cl 76505 1,3-Dihydroxy-benzene m-Dihydro) benzene m-Dioxybenzene m-Hydroquinone 3-Hydroxycyclohexadien-1-one 3-Hydroxyphenol m-Hydroxyphenol Resorcin Resorcine Classification Aromatic alcohol phenol Empirical CsHsOj Formula C6H,(OH)2... 

Monoesterification of a symmetrical dihydroxy aromatic compound can be effected by reaction with polymer-bound benzoyl chloride (Pyr, benzene, reflux, 15 h) to give a polymer-bound benzoate, which can be alkylated with diazomethane to form, after basic hydrolysis (0.5 M NaOH, dioxane, H2O, 25°, 20 h, or 60°, 3 h), a monomethyl ether. ... 

Chloranilic acid (2,5-dichloro-3,6-dihydroxy-l,4-benzoquinone)/57-5S-77 M 209.0, m 283-284° pK l.22, pK 3.01. A soln of 8g in IL of boiling water was filtered while hot, then extracted twice at about 50° with 200mL portions of benzene. The aq phase was cooled in ice-water. The crystals were filtered off, washed with three lOmL portions of water, and dried at 115°. It can be sublimed in vacuum. [J Phys Chem 61 765 1957.] The diacetate has m 182-185° [7 Am Chem Soc A6 1866 1924 Thamer and Voight J Phys Chem 56 225 7952]. 

Dihydroxy-3-methylanthraquinone (chrysophanic acid) [481-74-3] M 245.3, m 196 , PKesi(I) 8.2, pKest(2) 12.4. Crystd from EtOH or benzene and sublimed in a vacuum. 

Alternatively, 25.0 g of either 3j3,5a-dihydroxy-17a-methyl-17j3-carbomethoxyandrostan-6-one (Ilia) or 25.0 g of its 3)3-acetate (Hlb), are dissolved in dry tetrahydrofuran (1,250 ml, freshly distilled over lithium aluminum hydride) and dry benzene (2,000 ml) is added. Methyl magnesium bromide in ether solution (3 M, 750 ml) is added to the stirred solution and the resulting mixture is stirred at room temperature for 16 hours. An additional quantity of methyl magnesium bromide solution in ether (2M, 375 ml) is added, and 1,250 ml of the solvent mixture are distilled off. The resulting mixture is refluxed for 5 hours and worked up as described above, yielding compound (V) as a colorless oil. 

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