Metabolism lysergic acid diethylamide

Rosecrans, J. A., Lovell, R. A., and Freedman, D. X. (1967) Effects of lysergic acid diethylamide on the metabolism ofbrain 5-hydroxytryptamine. Biochem. Pharmacol., 16 2011-2021. 

Ishii and coworkers examined microbial transformations of lysergic acid and related compunds in order to clarify the metabolic pathway of LSD in mammals (162-164). Steptomyces lavendulae (IFM 1031) accomplished selective N-de-methylation at position N6 of lysergic acid diethylamide (LSD) (37) to afford nor-LSD (38) (162). On the other hand, S. roseochromogenes (IFM 1081) ac-... 

In parasitic flatworms, 5-HT serves a variety of functions from control of carbohydrate metabolism to intra- and interorganism (host-parasite) communication (36). Rhythmical movement is stimulated by 5-HT and related indoleamines (e.g., lysergic acid diethylamide) (7,8,37). This stimulatory effect, like the ACh inhibitory effect, can be obtained in the absence of the central ganglia suggesting a peripheral site of action (37). The stimulation of motility (increased contraction amplitude and frequency) in vitro suggests that 5-HT or a closely related indoleamine is an excitatory transmitter in both the trematodes F. hepatica (9, 37, 38), S. mansoni (11, 12, 39, 40), Clonorchis sinensis... 

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