Lymphoproliferative disease posttransplant

Special Precautions Risk of infections, leukopenia, thrombocytopenia, lymphoma, posttransplant lymphoproliferative disease or other malignancies Pregnancy Category C... 

Martin-Gomez MA, Pena M, Cabello M, Burgos D, Gutierrez C, Sola E, Acedo C, Bailen A, Gonzalez-Molina M. Posttransplant lymphoproliferative disease a series of 23 cases. Transplant Proc 2006 38 2448-50. 

NORFLOXACIN CICLOSPORIN t plasma concentrations of cido-sporin, with risk of nephrotoxicity, myelosuppression, neurotoxicity and excessive immunosuppression, with risk of infection and posttransplant lymphoproliferative disease Inhibition of CYP3A4-mediated metabolism of cidosporin these inhibitors vaiy in potency Monitor plasma cidosporin levels to prevent toxicity. Monitor renal function... 

Anderson P, Schroeder T, Hariharan S, First M. Incidence of posttransplant lymphoproliferative disease in OKT-3 treated renal transplant recipients. Clin Transplant 1993 7 582-5. 

Younes BS, McDiarmidSV, Martin MG, Vargas JH, Goss JA, Busuttil RW, Ament ME. The effect of immunosuppression on posttransplant lymphoproliferative disease in pediatric liver transplant patients. Transplantation 2000 70(l) 94-9. 

Figure 39-17 In situ hybridization (iSH) for the Epstein-Barr virus (EBV). ISH hybridization for EBV shows numerous positive signals (dark-blue spots) for EBV using the EBER-I probe.The tissue sample was obtained from a solid-organ transplant patient who developed widespread nodal and extranoda masses.The positive reaction for EBV In this assay supports a diagnosis of posttransplant lymphoproliferative disease. (See Color Plate 6.)...

Figure 39-17 (Color Plate 6) shows an example of positive EBV in situ hybridization in a case of posttransplant lymphoproliferative disease.

Posttransplant lymphoproliferative disease Paraneoplastic pemphigus IgM polyneuropathies Myasthenia gravis Graft versus host disease... 

Port FK (2003) Organ donation and transplantation trends in the United States, 2001. Am J Transpl 3 [Suppl 4] 7-12 Reyes J, Green M, Bueno J et al (1996) Epstein-Barr virus associated posttransplant lymphoproliferative disease after intestinal transplantation. Transplant Proc 28 2768-2769 Starzl TE, Rowe MI, Todo S et al (1989) Transplantation of multiple abdominal viscera. J Am Med Assoc 261 1449-1457... 

Evans syndrome, refractory to immunosuppressive therapy Graft vs. host disease, chronic, steroid refractory Pemphigus vulgaris, severe Posttransplant lymphoproliferative disorder... 

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