Lymphomatoid papulosis

Unlabeled Uses Dermographism, eczema, hypereosinophilic syndrome, hypopig-mented sarcoidosis, ichthyosis linearis circumflexa, lymphomatoid papulosis, mycosis fungoides, palmoplantar pustulosis, pruritus, scleromyxedema, systemic sclero-... 

Lupus erythematosus (SEDA-15, 140) (SEDA-17, 183) Lymphomatoid papulosis (SEDA-16, 151)... 

Benjamin RW+, Pediatr Dermatol 24(3), 246 (2007) Geddes R,) Orthop Sports Phys Ther 37(2), 65 Lymphomatoid papulosis... 

Davis TH, Morton CC, Miller-Cassman R, et al. Hodgkin s disease, lymphomatoid papulosis, and cutaneous T-cell lymphoma derived from a common T-cell clone. N Engl J Med. 1992 326 1115-1122. 

Boulland ML, Wechsler J, Bagot M, et al. Primary CD30-positive cutaneous T-cell lymphomas and lymphomatoid papulosis frequently express cytotoxic proteins. Histopathology. 2000 36(2) 136-144. 

Herbst H, Sander C, Tronnier M, et al. Absence of anaplastic lymphoma kinase (ALK) and Epstein-Barr virus gene products in primary cutaneous anaplastic large cell lymphoma and lymphomatoid papulosis. Br J Dermatol. 1997 137(5) 680-686. 

In contrast to RAH/ALCL, lymphomatoid papulosis (LYP) follows a more consistently indolent course, and, as such, it is still not uniformly accepted as a malignant disease. LYP may arise in virtually any cutaneous or mucocutaneous surface, although axial sites are most common. The typical lesions are small papules that may undergo central hemorrhage and necrosis before healing... 

Kaudewitz P, Burg G. Lymphomatoid papulosis and Ki-1 (CD30)-positive cutaneous large cell lymphomas. Semin Diagn Pathol. 1991 8 117-124. 

Drews R, Samel A, Kadin ME. Lymphomatoid papulosis and anaplastic large cell lymphomas of the skin. Semin Cutan Med S rg. 2000 19 109-117. 

Liu HL, Hoppe RT, Kohler S, et al. CD30+ cutaneous lym-phoproliferative disorders the Stanford experience in lymphomatoid papulosis and primary cutaneous anaplastic large cell lymphoma. J Am Acad Dermatol. 2003 49 1049-1058. 

Cerio R, Black MM. R ressing atypical histiocytosis and lymphomatoid papulosis variants of the same disorder Br J Dermatol. 1990 123 515-521. 

Yashiro N, Kitajima J, Kobayashi H, et al. Primary anaplastic large-cell lymphoma of the skin a case report suggesting that regressing atypical histiocytosis and lymphomatoid papulosis are subsets. / Am Acad Dermatol. 1994 30 358-363. 

Steinhoff M, Hummel M, Anagnostopoulos I, et al. Single-cell analysis of CD30+ cells in lymphomatoid papulosis demonstrates a common clonal T-cell origin. Blood. 2002 15 578-584. 

Topical carmustine has been used for the treatment of mycosis fiingoides, lymphomatoid papulosis and parapsoriasis en plaques. Zackheim (1994) reported their experience of 172 patients with patch-plaque-stage mycosis fungoides treated with topical i,3-bis(2-chlo-roethyl)-i-nitrosourea solution. Complete blood counts were determined once each month during treatment. Mild, reversible myelosuppression occurred in less than 10% of patients using 20 mg/day total-body application and was rare in those using 10 mg/ day. 

A 28-year-old man with a 15-year history of juvenile rheumatoid arthritis developed lymphomatoid papulosis after two courses, and then a third course, of adalimumab. Each time the mAb was withdrawn, the condition resolved only to reappear on resumption of therapy [84 ]. 

Park J-H, Lee J, Lee JH, Lee D-Y, Koh E-M. Lymphomatoid papulosis in a patient treated with adalimumab for juvenile rheumatoid arthritis. Dermatology 2012 225(3) 259-63. 

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