Luteolin 7-methyl ether

Phlomis consists of about 100 species, a dozen of which occur in Mediterranean Europe (Mabberley, 1997, p. 549). The study of interest here involves a study of the flavonoids of R lychnitys L., a small plant native to Mediterranean Spain (Tomas et ah, 1986). Those workers identified the common flavones apigenin, luteolin, and luteolin 3 -methyl ether (chrysoeriol) 7-0-glucosides and their respective /7-coumaroyl derivatives. A brief review of the literature revealed that Mediterranean species of Phlomis are characterized by the presence of the flavone methyl ether, whereas continental species appear to lack 0-methylated flavones. Species from India have been reported to lack flavones but accumulate flavonols. The suggestion was made that accumulation of flavonols represents an ancestral feature of the genus. 

Flaveria haumanii, Cotinus coggygria, Coreopsis spp. and pre Columbian Andean textiles Okanine, luteolin, butein (as aglycones, glycosides or as methyl ethers), quercetin, isorhamnetin (as sulfate esters), sulfuretin, fisetin, hydroxybenzoic acids HCI/Me0H/H20, HCOOH/MeOH A H20 B ACN C H20 with HCOOH 254, 350 nm/ESI (+) Column C4 7... 

Trihydroxy-4 -methoxyflavone (Diosmetin, Luteolin 4 -methyl ether)... 

Luteolin 5-methyl ether 7-Xylosyl(l —> 6)glucoside Luteolin 7-methyl ether... 

Luteolin 3 -methyl ether (chrysoeriol) 7-a-L-Arabinofuranosyl(l —> 6)glucoside 7-Apiosyl(l —> 6)glucoside 7-Neohesperidoside 7,4 -Diglucuronide 7-(3"-Z-p-coumaroylglucoside)... 

Feruloylglucuronosyl) (1 2)glucuronide 7-[Glucuronosyl(l 3)(2" -feruloylglucuronosyl)] (1 2)glucuronide Luteolin 4 -methyl ether (diosmetin)... 

Some bioactive flavones include aldose reductase inhibitors (apigenin 4 -methyl ether (acacetin), apigenin 7-0-apioside (apiin), 5,7-dihydroxyflavone (chrysin) and luteolin) antiinflammatory 5-LOX inhibitors (5,6,7-trihydroxyflavone (baicalein), 5,6,3, 4 -tetrahydroxy 7-methoxyflavone (pedalitin), 5,3, 4 -trihydroxy 6,7-dimethoxyflavone (cirsiliol, 6-0-methylpedalitin) and flavone) a COX inhibitor (flavone) iodothyronine deiodinase inhibitors (acacetin, chrysin and luteolin) a NADH and succinate dehydrogenase inhibitor (luteolin) millet-derived, goitrogenic inhibitors of thyroid peroxidase (flavone C-glycosides orientin and vitexin) and protein kinase inhibitors (acacetin, apigenin, baicalein, flavone, luteolin, 5,7,3, 4, 5 -pentahydroxyflavone (tricetin) and tricetin 3, 4, 5 -trimethyl ether). 

Chrysoeriol (= Luteolin 3 -methyl ether 5,7,4 -Trihydroxy-3 -methoxy-flavone) (flavone) Chrysosplenol B (= 5,4 -Dihydroxy-3,6,7,3 -tetramethoxyflavone) (flavonol)... 

Pisutthanan et al. (27) isolated six flavonoids out of which three were reported in this plant for the first time. They include 3,5,4 -trihydroxy-7-methoxyflavanone 5,7,3 -trihydroxy-5 -methoxyflavanone and 3,5,7-trihydroxy-4 -methoxyflavanone. Ling et al. (28) also isolated a total of eleven flavonoids from the leaf extract and identified them as eriodictyol 7,4 -dimethyl ether, quercetin 7,4 -dimethyl ether, naringenin 4 -methyl ether, kaempferol 4 -methyl ether, kaempferol 3-0-mtinoside, taxifolin 4 -methyl ether, taxifolin 7-methyl ether and quercetin 4 -methyl ether. Suksamram et al. (23) isolated the flavanones, isosakuranetin (5,7-dihydroxy-4 -methoxyflavanone), persicogenin (5,3 -dihydroxy-7,4 -dimethoxyflavanone), 5,6,7,4 -tetramethoxyflavanone and 4 -hydroxy-5,6,7-trimethoxyflavanone, the chalcones, 2 -hydroxy-4,4, 5, 6 -tetramethoxychalcone and 4,2 -dihydroxy-4, 5, 6 -trimethoxychalcone, and the flavones, acacetin (5,7-dihydroxy-4 -methoxyflavone) and luteolin (5,7,3, 4 -tetrahydroxyflavone) from the flowers. 

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