Luteinizing hormone-releasing derivative

Key S. and Wray S. (2000). Two olfactory placode derived galanin subpopulations luteinizing hormone-releasing hormone neurones and vomeronasal cells. J Neuroendocrinal 12, 535—545. 

Matsubara, K., et al. 1995. Improvement of nasal bioavailability of luteinizing hormone-releasing hormone agonist, buserelin, by cyclodextrin derivatives in rats. J Pharm Sci 84 1295. 

Nagy, A., Schally, A. V., Armatis, P, et al. Cytotoxic analogs of luteinizing hormone-releasing hormone containing doxorubicin or 2-pyrrolinodoxorubicin, a derivative 500-1000 times more potent. Proc. Natl. Acad. Sci. USA 94 652-656, 1996. 

The first 34 residues of human parathyroid hormone (PTH) [190] were identified from the Cl mass spectra of their phenylthiohydantoin derivatives by repeated Edman degradations on a Beckmann Sequencer [163]. In a similar way as part of the characterisation of ovine hypothalmic luteinizing hormone-releasing factor (LRF), the trimethylsilyi derivatives of the phenylthiohydantoins from Edman degradation were confirmed by MS [191]. 

Cetrorelix is a decapeptide with a sequence derived from luteinizing hormone releasing hormone and subsequently modified. Five of the ten amino acids present are in the D configuration. The peptide is protected from degradation by means of C- and TV-terminal protective groups and was used as standard. 

---