Luteinizing agonists

LH-RH (Luteinizing Hormone-Releasing Hormone) agonists are drugs that inhibit the secretion of sex hormones. In men, LH-RH agonists cause testosterone levels to fall. In women, LH-RH agonists cause the levels of estrogen and other sex hormones to fall. [Pg.690]

Hormonal therapies that have been studied in the treatment of primary or early breast cancer include antiestrogens, oophorectomy, ovarian irradiation, luteinizing hormone-releasing hormone (LHRH) agonists, and aromatase inhibitors. [Pg.1314]

Outline the role of luteinizing hormone-releasing hormone (LHRH) agonists in the treatment of prostate cancer. [Pg.1357]

Androgen ablation with a luteinizing hormone-releasing hormone (LHRH) agonist plus an antiandrogen should be used prior to radiation therapy for patients with locally advanced prostate cancer to improve outcomes over radiation therapy alone. [Pg.1357]

Marks LS. Luteinizing hormone-releasing hormone agonists in the treatment of men with prostate cancer Timing, alternatives, and the 1-year implant. Urology 2003 62(6 suppl 1) 36—42. [Pg.1369]

The major initial treatment modality for advanced prostate cancer is androgen ablation (e.g., orchiectomy or luteinizing hormone-releasing hormone [LHRH] agonists with or without antiandrogens). After disease progression, secondary hormonal manipulations, cytotoxic chemotherapy, and supportive care are used. [Pg.727]

K. Abe, T. Irie, and K. Uekama. Enhanced nasal delivery of luteinizing hormone releasing hormone agonist buserelin by oleic acid solubilized and stabilized in hydroxypropyl-/S-cyclodextrin. Chem Pharm Bull 43 2232-2237 (1995). [Pg.231]

N. I. Chu, R. L. Chan, K. M. Hama, M. D. Chaplin, Disposition of Nafarelin Acetate, a Potent Agonist of Luteinizing Hormone-Releasing Hormone, in Rats and Rhesus Monkeys , Drug Metab. Dispos. 1985, 13, 560 - 565. [Pg.380]

Bergquist, C., Nillius, S. J., and Wide, L. (1979). Inhibition of ovulation in women by intranasal treatment with a luteinizing hormone-releasing agonist. Contraception 19, 497-506. [Pg.435]

Klijn JG, Blarney RW, Boccardo F, Tominaya T, Duchateau L, Sylvester R. Combined tamoxifen and luteinizing-hormone (LHRH) agonist versus LHRH agonist alone in premenopausal advanced breast cancer a meta-analysis of four randomized trials. J Clin Oncol 2001 19 343-53. [Pg.725]

Asano, M.,Fukuzaki,H., Yoshida, M., Kumakura, M., Mashimo, T., Yuasa, H., Imai, K., Yamanaka, H., Kawaharada, U., Suzuki, K. (1991). In vivo controlled release of a luteinizing hormone-releasing hormone agonist from poly(DL-lactic acid) formulation of varying degradation pattern. Int. J. Pharm., 67,61-11. [Pg.459]

Olivennes F, Belaisch-Allart J, Emperaire JC, Dechaud H, Alvarez S, Moreau L, Nicollet B, Zorn JR, Bouchard P, Frydman R. Prospective, randomized, controlled study of in vitro fertilization-embryo transfer with a single dose of a luteinizing hormone-releasing hormone (LH-RH) antagonist (cetrorelix) or a depot formula of an LH-RH agonist (triptorelin). Fertil Steril 2000 73(2) 314-20. [Pg.494]

Matsubara, K., et al. 1995. Improvement of nasal bioavailability of luteinizing hormone-releasing hormone agonist, buserelin, by cyclodextrin derivatives in rats. J Pharm Sci 84 1295. [Pg.392]

Luteinizing Hormone-Releasing Hormone (LHRH) Agonists/Antagonists... [Pg.229]

LHRH is a decapeptide hormone (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2) which is synthesized in the hypothalamus and induces the release of gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) into the systemic circulation. LHRH agonists are commonly used to treat prostate cancer, while antagonists of LHRH are useful for many indications in men and women, such as breast and prostate cancer. [Pg.229]

Physiological aspects of luteinizing hormone releasing factor and sex steroid actions the interrelationship of agonist and antagonist... [Pg.151]

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