Lupinus argenteus

Carey, D.B. and Wink, M. (1994). Elevational variation of quinolizidine alkaloid contents in a lupine Lupinus argenteus) of the Rocky Mountains, J. Chem. EcoL, 20, 849-857. 

Wink, M. and Carey, D.B. (1994). Variability of quinolizidine alkaloid profiles of Lupinus argenteus (Fabaceae) from North America, Biochem. Systematics EcoL, 22, 663-669. 

Thermopsine Quinolizidine Lupinus texensis Lupinus argenteus Castilleja Integra Castilleja indivisa Castilleja miniata... 

Recently, it has been demonstrated that medicinal plants contain MDR pump inhibitors that actually enhance the activity of their own natural antimicrobial compounds. Plant amphipathic cations, such as berberine, have been shown to be good MDR substrates. Recent research has shown that in addition to berberine, Berberis species produce 5 -methoxyhydnocarpin-D, Fig. 10, an MDR inhibitor that enhances the action of this compound. In addition, isoflavones isolated Ifom Lupinus argenteus were found to enhance the antibacterial activity of a-linolenic acid, also found in the same plant [99]. 

Figure 8. Changes in alkaloid content (mg g wet weight, left axis) and flower production per plant (number, one year obsv. right axis) in Lupinus argenteus with elevation. Data from Carey and Wink, 1994 re-plotted by author.

The alkaloids of the overground parts of lupinus argenteus Pursh. var. stenophyiius... 

Arslanian, R L., Harris, G H., and Stenmtz, F. R. (1990) New qumolizidine alkaloids from Lupinus argenteus and its hosted root parasite Castilleja sulphurea. Stereochemistry and conformation of some naturally occuring cyclic carbinolamides. y. Org Chem, 55, 1204-1210. 

Jindal SP, Lutz T (1986) Ion cluster techniques in drug metabolism use of labelled and unlabelled cocaine to facilitate metabolite identification. J Anal Toxicol 10 150-155 Jindal SP, Lutz T, Vestergaard P (1979) Gas-liquid chromatographic-mass spectrometric determination of lidocaine in an illicit sample of cocaine. J Chromatogr 179 357-360 Keller WJ, Zelenski SG (1978) Alkaloids from Lupinus argenteus var. stenophyllus. J Pharm Sci 67 430-431... 

Plants from five species of Pedicularis (Scrophularia-ceae) take up alkaloids from their host plants. Those of Pedicularis groenlandica and P. bracteosa take up senecionine (5) from the host Senecio triangularis. Those of Pedicularis crenulata contain anagyrine (Fig. 30.1) (a quinolizidine alkaloid) from the host Thermopsis divaricarpa. Plants of Pedicularis racemosa contain quinolizidine alkaloids from a Lupinus argenteus hybrid (Schneider and Stermitz, 1990). 

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