Lunsford

Introduction - Following the format of previous editions of this chapter the discussion of compounds Is divided on the basis of established or projected clinical use and to a lesser extent on the basis of pharmacological properties rather than on the basis of chemical structure. An effort was made to exclude those depressants more properly classified as antipsychotics and antianxiety agents which are discussed In Chapter 1, although there Is undoubtedly some overlap. Further, an effort was made to scan all of the published literature In the subject therapeutic areas, but only those compounds with more than preliminary pharmacological screening data or representative of new structures were selected for Inclusion In the review. 

Sedatives and Hypnotics - The hypnotic properties of the theophylline de-rlvative ETTT (l) In mice, rats, rabbits and dogs has been describecP. The activity was related to the dose but at active doses dogs experienced respiratory stimulation, vomiting and defecation. 

The hypnotic efficiency of N-methylbutlsol (II) was evaluated in patients against the provocation to awaken to empty the bladder. The 

A study of the urinary metabolites of the hypnotic, flurazepam hydrochloride, Ro 5-6901 (III), in the dog reveals non-conjugated (IV) and (V), conjugated (IV), (V), (VI) and (VIII) and a phenolic derivative of (VII). Human urine contained only the glucosuronic acid or sulfate conjugate of (VI). The synthesis and a comparison of the pharmacology of flurazepam hydrochloride with that of other 1,4-benzodiazepines has been reported , as well as the clinical use of this compound as a hypnotic.  

Anticonvulsants - Carbamazepine (IX), already commercially available in Europe, was cleared by the United States Food and Drug Administration for the indication of relief of pain of trigeminal neuralgia . 

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Delgass W N, Haller G L, Kellerman R and Lunsford J H 1979 Spectroscopy in Heterogeneous Catalysis (New York Academic)... 

Electron Spin Resonance in Catalysis Jack H. Lunsford... 

The two mechanisms proposed to account for the partial oxidation of methane to syngas may be dedgnated as the IPO (Indirect Partial Oxidation) mechanism and the DPO (Direct Partial Oxidation) mechanism. The IPO mechanism was proposed by Prette et al [16] and Lunsford et al [12]. They think CO and H2 are the products of indirect reaction, the overall reaction of the POM reaction is composed of three different reactions... 

It is often said that the property of acidity is manifest only in the presence of a base, and NMR studies of probe molecules became common following studies of amines by Ellis [4] and Maciel [5, 6] and phosphines by Lunsford [7] in the early to mid 80s. More recently, the maturation of variable temperature MAS NMR has permitted the study of reactive probe molecules which are revealing not only in themselves but also in the intermediates and products that they form on the solid acid. We carried out detailed studies of aldol reactions in zeolites beginning with the early 1993 report of the synthesis of crotonaldehyde from acetaldehyde in HZSM-5 [8] and continuing through investigations of acetone, cyclopentanone [9] and propanal [10], The formation of mesityl oxide 1, from dimerization and dehydration of... 

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