Lowest level of method validation

Today, when a pesticide with no detectable residues is registered for use, a Tolerance or maximum residue limit (MRL) is established at the lowest concentration level at which the method was validated. However, for risk assessment purposes it would be wrong to use this number in calculating the risk posed to humans by exposure to the pesticide from the consumption of the food product. This would be assuming that the amount of the pesticide present in all food products treated with the pesticide and for which no detectable residues were found is just less than the lowest level of method validation (LLMV). The assumption is wrong, but there is no better way of performing a risk assessment calculation unless the limit of detection (LOD) and limit of quantification (LOQ) of the method were clearly defined in a uniformly acceptable manner. 

Finally, it is important to define the lowest level of method validation (LLMV). The LLMV is defined as the lowest concentration level expressed in terms of amount of analyte in the matrix, at which the method (extraction/analysis procedure) was validated or proven to be capable of reliably quantifying. 

According to the definition the lowest level of method validation (LLM V), the standard deviation of the concentration of the anal5rte in these fortified samples (ocloq) is the [Pg.179]

---

See also in sourсe #XX -- [ , , , ]

---