Low wettability drug

Development of a Robust Formulation of Low Wettability Drug during Early... 

Case Study—The Choice of Capsule or Tablet Formulation for Early Clinical Trials Involving Low Wettability Drug... 

The factors described earlier that affect the solubility of a lead compound when choosing a particular salt form—a polymorphic form—a specific crystalline form directly affects the most critical parameter that determines the drug activity, which is the dissolution rate in the biological milieu. The first step in the commencement of dissolution is the wettability of solid particles—there is a direct correlation between wettability and bioavailability. As the milieu of drug administration sites is mostly aqueous in nature, low wettability makes the particles less hygroscopic. 

Incorporation of surfactants in HPMC compressed matrices has been shown to cause retardation of drug release [110-112]. The first mechanism postulated was that anionic surfactants were capable of binding to nonionic polymers to increase the viscosity [110], More recently, drug-surfactant ionic interaction has been put forward instead, resulting in the formation of a complex with low solubility in water [111,112]. Note that such an effect can unintentionally occur upon putting some surfactant into the release medium in order to increase wettability. 

---