Low-molecular-weight water-soluble chitosan

Low Molecular Weight Water-Soluble Chitosan with Free Amine Croup for Drug Delivery 329... 

Jang, M. J., Kim, D. G., Jeong, Y. L, Jang, M. K., and Nah, J. W. 2007. Preparation and characterization of low molecular weight water soluble chitosan gene carrier fractioned according to molecular weight. Polymer(Korea) 36 555—561. 

A novel fiber-reactive chitosan derivative was synthesized in two steps from a chitosan of low molecular weight and low degree of acetylation. First, a water-soluble chitosan derivative, N-[(2-hydroxy-3-trimethylammonium)-... 

Lee M, Nah JW et al (2001) Water-soluble and low molecular weight chitosan-based plasmid DNA delivery. Pharm Res 18 427 31... 

Poly(ethylene glycol) (PEG), also known as poly(ethylene oxide) (PEO), is a hydrophilic, biocompatible polyether. PEG usually refers to a material with relatively low molecular weight (e.g., several thousands), while PEO to a material with high molecular weight (e.g., over tens or hundreds of thousands). PEO is wafer soluble and therefore can be electrospun into nanofibres from its water solution (Deitzel et al., 2001). However, water solubility makes the material unstable in a biological environment. Consequently, PEO or PEG is usually used in combination with other natural (e.g., collagen, chitosan) or synthetic polymers (e.g., PLA) in blends or copolymers (Subramanian et al., 2005 Szentivanyi et al., 2009). 

Gerasimenko, DV Avdienko, ID Bannikova, GE Zueva, OY Varlamov, VP. Antibacterial effects of water-soluble low-molecular-weight chitosans on different microorganisms. Applied Biochemistry and Microbiology, 2004, 40, 253-257. 

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