Lonophore

Burger M T, A Armstrong, F Guamieri, D Q McDonald and W C Still 1994. Free Energy Calculations in Molecular Design Predictions by Theory and Reality by Experiment with Enantioselective Podand lonophores. Journal of the American Chemical Society 116 3593-3594. 

M. Dobler, lonophores and Their Structures, Wiley, New York, 1981. 

COMPUTER MODELING OF lONOPHORE-BASED ION-SELECTIVE MEMBRANES USING MULTISPECIES APPROXIMATION... 

All of the transport systems examined thus far are relatively large proteins. Several small molecule toxins produced by microorganisms facilitate ion transport across membranes. Due to their relative simplicity, these molecules, the lonophore antibiotics, represent paradigms of the mobile carrier and pore or charmel models for membrane transport. Mobile carriers are molecules that form complexes with particular ions and diffuse freely across a lipid membrane (Figure 10.38). Pores or channels, on the other hand, adopt a fixed orientation in a membrane, creating a hole that permits the transmembrane movement of ions. These pores or channels may be formed from monomeric or (more often) multimeric structures in the membrane. 

Active Transport or Ions Using Synthetic lonophores Derived... 

Hilgenfeld, R., and Saenger, W. Structural Chemistry of Natural and Synthetic lonophores and their Complexes with Cations. 101, 3-82 (1982). 

Polyether Antibiotics Naturally Occurring Acid lonophores, Westley, J. W., Ed., Marcel Dekker New York, 1982, Vol. 1-2. 

Assay of lonophore Activity. Ionophoretic activities on rat liver mitochondria and liposomes were performed as described previously (72). 

Origin, Chemistry, and Mechanisms of Action of a Repellent, Presynaptic Excitatory, lonophore... 

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