Long-range effects of carcinogens

For extensive treatment of long range effects of carcinogens on DNA, see Ladik and Fomer [130],... 

In this section we should like to point out the possibility of two different kinds of solitons (non-linear quasi particles) in a nucleotide base stack. They quite probably play an important role in long-range effects of chemical carcinogens and direct hits of ionizing radiations along a DNA double helix. In this way they may play an important role in the activation of oncogenes or in the inactivation of antioncogenes. 

N. DQDDI > ETHICON, INC. You have made copolymers from lactic acid and csprolactone and you said that you have not observed any tissue reactions. Have you looked at axiy long range effects of these copolymers, e.g., have you looked at the carcinogenicity of these polymers ... 

Further possibilities for long-range effects of chemical carcinogens are provided by the change or occurrence of different collective states in these complex polymers. These collective states can be vibrational or conformational solitons, Mott insulator states, Peierls instabilities, plasmon-type states, charge and spin density waves, excitonic insulator states, etc. Here only one example (which has been worked out in some detail), namely a conformational soliton caused by carcinogen binding, will be discussed. 

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