Lomaiviticins

Prior to our work in this area, three groups reported syntheses of various kinamycins. These are presented in chronological order below. A large number of synthetic studies toward the lomaiviticins have been reported, although these are not discussed here [23]. [Pg.46]

Kinamycin and Lomaiviticin Antibiotics Importance of Diazo Group. . . 140... [Pg.142]

Abstract Diazonium salts have been previously used to cleave DNA via generation of carbon centered radicals and cations. Efforts have been made in the past decade or so to develop diazo compounds and a-diazoketones for physiologically relevant DNA cleavage. These efforts, coupled with their relevance to the mechanism of action of kinamycin and lomaiviticin antibiotics and other naturally occurring diazo compounds, will be discussed. [Pg.142]

Keywords Alkylation Diazo Diazonium DNA cleavage Kinamycin antibiotics Lomaiviticin antibiotics... [Pg.142]

Colis LC, Woo CM, Hegan DC, Li Z, Glazer PM, Herzon SB. The cytotoxicity of (—)-lomaiviticin A arises from induction of double-strand breaks in DNA. Nat Chem. 2014 6 504-510. [Pg.195]

Shair and coworkers relied on an intramolecular cycloaddition in their enantioselective approach to lomaiviticin A... [Pg.393]

Micromonospora lomaivitiensis Ascidian (Polysyncraton lithostrotum) Lomaiviticins Antibiotic, cytotoxic Meet of, 2001... [Pg.97]

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