Logan synthesis

Sheehan, J.C. Henery-Logan, K.R. (1959) The Total Synthesis of Penicillin V. Journal ofthe American Chemical Society, 81, 3089-3093. 

Atherton E, Logan CJ, Sheppard RC, Peptide synthesis, part 2 Procedures for solid phase synthesis using W-lluorcnylmcthoxycarbon-ylamino acids on polyamide supports Synthesis of substance P and of acyl carrier protein 64—74 decapeptide. J Chem Soc Perkin Trans 1 1981 ... 

A Atherton, H Fox, D Harkiss, CJ Logan, RC Sheppard, BJ Williams. A mild procedure for solid phase peptide synthesis Use of fluorenylmethoxycarbonylamino-acids. J Chem Soc Chem Commun 537, 1978. 

The structure of the monoterpenoid alkaloid alangiside (115 R = H) has been confirmed by synthesis of the O-methyl ether (115 R = Me) from secologanin and 3-hydroxy-4-methoxyphenethylamine 202 the isolation of loganic acid from the same plant (Alangium lamarckii) is consistent with biosynthetic theory. 

Formation of p-Lactams, Peptides and Oligonucleotides. The intramolecular cyclization technology to form /8-lactams using DCC in the condensation reaction was used by Sheehan and Henery-Logan in the total synthesis of penicilline in 1957. They also found that N-trityl penicilloates are cyclized with diisopropylcarbodiimides. Other p-lactames, such as cephalothin lactone and (—)-thienamicin are similarly constructed. The latter synthesis proceeds in a stereospecific manner and DCC is used in combination with triethylamine to give a 93 % yield of the /3-lactam 661. 

War II, attempts were made in many laboratories to synthesize penicillin 19> 32. The first rational total synthesis of penicillin V was achieved by Sheehan and Henery-Logan in... 

Logan, A., Frautschy, S. A., Gonzalez, A.-M., and Baird, A., A time course of the focal elevation of synthesis of basic fibroblast factor and one of its high aflmity receptors (fig) following a locahsed cortical brain injury, J. Neurosci., 12, 3628,1992. 

In Figure 1 penicillin nomenclature is presented (5, 19). A total synthesis of penicillin V (1957) and a total general synthesis of penicillins (1959) have been reported by Sheehan and Henery-Logan (16, 17, 18). Although total synthesis is the most elegant from an organic chemical point of view, also in principle the most flexible, the numerous steps involved (albeit each proceeds in good yield) render total synthesis noncompetitive industrially with partially synthetic techniques at the present time. 

It is parenthetically of historical interest that the long-sought total synthesis of a penicillin (V) had been achieved 2 years earlier by Sheehan and Henery-Logan (1957) in an... 

Sheehan 1C, Henery-Logan KR, A general synthesis of the penicillins, 7. Biol. Chem. 1959 81 5838-5839. 

P. Card and G. D. Soraru, Sol-gel processing of continuous fiber reinforced composites by the liquid infiltration and pyrolysis (LIP) method, in Innovative Processing and Synthesis of Ceramics, Glasses and Composites, N. P. Bansal, K. V. Logan, and J. P. Singh (Eds), Ceramic Transactions, Vol. 85, 1997, pp. 405-416. The American Ceramic Society, Westerville, Ohio, USA. 

In one of the earliest attempts, Henery-Logan and Limburg reported the synthesis of A -phenylaceturylaziridine-2-carboxylic acid from benzyl a,0-dibromo-proprionate [255]. Due to its aziridine ring, this compound may be considered... 

Subsequently Sheehan and Henery-Logan described a synthesis of the nucleus of the penicillin molecule, 6-aminopenicillanic acid (III). Circum-... 

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