LOAEC concentration

For systemic effects observed in inhalation smdies, the determining factor for effects to occur at the systemic target is generally the total dose rather than the concentration of the chemical in the air. In such cases, a tolerable intake (expressed as mg/kg body weight per day, or mg/m depending on the standard to be derived, i.e., a tolerable intake in its strict meaning, or a tolerable concentration) is estabhshed from the NOAEC, or LOAEC, derived in the inhalation smdy and adjusted for continuous exposure. 

LOAEC Lowest-Observed-Adverse-Effect Concentration... 

LOAEC/L Lowest-observed-adverse-effect concentration/level. The lowest level of exposure to a chemical in a test that causes statistically significant differences from the controls in a measured negative response. 

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