Rofecoxib Lisinopril

One report has described a case of increased blood pressure in a patient taking rofecoxib and lisinopril (122). 

The blood pressure of a 59-year-old man with hypertension and normal renal function rose when rofecoxib 25 mg/day was added to lisinopril 10 mg/day (from an average of 135/80-85 to 168/98 mmHg within 5 weeks). Four days after rofecoxib was withdrawn the blood pressure was 127/78 mmHg. Rechallenge with the same dose of rofecoxib produced the same effect and the blood pressure fell when the dosage of lisinopril was increased to 20 mg/day on continuous rofecoxib. The authors did not report on the course of renal function. 

Clinically important, potentially hazardous interactions with ciprofloxacin, fluvoxamine, lisinopril, phenytoin, rofecoxib... 

The manufacturer of rofecoxib noted that in patients with mild-to-moder-ate hypertension, rofecoxib 25 mg daily, taken with benazepril 10 to 40 mg daily, for four weeks, was associated with a small attenuation of the antihypertensive effect (average increase in mean arterial pressure of 2.8 mmHg). Similarly, a case report describes a patient taking lisinopril 10 mg daily whose blood pressure rose from 127/78 to 143/89 mmHg when he was given rofecoxib 25 mg daily. His blood pressure was controlled by increasing the dose of lisinopril to 20 mg daily. ... 

Brown CH. Effect of rofecoxib on the antiltypertensive activity of lisinopril. Ann Pharmaco-ther (2000) 34, 1486. 

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