5-Lipoxygenase, polymorphisms

Lipoxygenase AVNTR polymorphism in 100 bp upstream from the ATG start codon is associated with transcription efficiency. Differences in response to 5-lipoxygenase inhibitors and leucotriene receptor antagonists. 

Anderson W, Kalberg C, Edwards L et al. Effects of polymorphisms in the promoter region of 5-lipoxygenase and LTC4 synthase on the clinical response to Za-firlukast and Fluticasone. Eur Respir J 2000 16 183s. 

Anderson, W., et al., "A Single Nucleotide Polymorphism in the 5-Lipoxygenase Gene is Associated with a Reduced Response to Leukotriene Antagonists," Am. Rev. Respir. Crit. Care Med., 163(5), A198 (2000). 

Manev H, Manev R. (2006) 5-Lipoxygenase (ALOX5) and FLAP (ALOX5AP) gene polymorphisms as factors in vascular pathology and Alzheimer s disease. Med Hypotheses. 66, 501-503. 

Kedda MA, Worsley P, Shi J, Phelps S, Duffy D, Thompson PJ. (2005) Polymorphisms in the 5-lipoxygenase activating protein (ALOX5AP) gene are not associated with asthma in an Australian population. Clin Exp Allergy. 35, 332-338. 

Kim SH, Bae JS, Suh CH, Nahm DH, Holloway JW, Park HS. (2005) Polymorphism of tandem repeat in promoter of 5-lipoxygenase in ASA-intolerant asthma a positive association with airway hyperresponsiveness. Allergy. 60, 760-765. 

Goodman JE, Bowman ED, Chanock SJ, Alberg AJ, Harris CC. (2004) Arachidonate lipoxygenase (ALOX) and cyclooxygenase (COX) polymorphisms and colon cancer risk. Carcinogenesis. 25, 2467-2472. 

Choi JH, Park HS, Oh HB, et al. (2004) Leukotiiene-related gene polymorphisms in ASA-intolerant asthma an association with a haplotype of 5-lipoxygenase. Hum Genet. 114, 337-344. 

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