Liposomes local concentration

Similar to Voltaren" Emulgel, oily droplets of an eutectic mixture of lidocaine and prilocaine are dispersed in a hydrogel to provide local anesthesia to the skin for injections and siugical treatment (Emla cream). A further possibility is the dermal administration of a liposome dispersion as a spray (Heparin PUR ratiopharm Spriih-gel "). After administration, water and isopropylic alcohol evaporate partially resulting in an increase of concentration and in a transition from the initial liposome dispersion into a lamellar liquid crystal [32]. The therapeutic effect appears to be influenced favorably by the presence of lecithins rather than by the degree of liposome dispersion. 

Liposomes have been used in the local delivery of drugs to the oral mucosa. Farshi et al. [96] studied the biodistribution of dexamethasone sodium phosphate (DSP) encapsulated in multilamellar vesicle (MLV) liposomes labeled with 99mTc in ulcerated and intact oral mucosae of rats. The liposomes were found to localize the drug in the ulcerated area and increase local drug concentration while decreasing systemic concentration. 

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