Lipoproteins factors affecting

Figure 26-5. Factors affecting cholesterol balance at the cellular level. Reverse cholesterol transport may be initiated by pre 3 HDL binding to the ABC-1 transporter protein via apo A-l. Cholesterol is then moved out of the cell via the transporter, lipidating the HDL, and the larger particles then dissociate from the ABC-1 molecule. (C, cholesterol CE, cholesteryl ester PL, phospholipid ACAT, acyl-CoA cholesterol acyltransferase LCAT, lecithinicholesterol acyltransferase A-l, apolipoprotein A-l LDL, low-density lipoprotein VLDL, very low density lipoprotein.) LDL and HDL are not shown to scale.

Scanu, A. M., Factors affecting lipoprotein metabolism. Advan. Lipid Res. 3, 63-138 (1965). 

Anderson, M. 1982a. Factors affecting the distribution of lipoprotein lipase activity between serum and casein micelles in bovine milk. J. Dairy Res. 49, 51-59. 

TABLE 2 Formulation Factors Affecting Metabolism as Lipoproteins, Recognition by Mononuclear Phagocyte System (MPS), and Elimination from Blood Circulation of Second- and Third-Generation Nanosized Emulsions after Parenteral Administration... 

Factors Affecting Plasma Lipids and Lipoproteins with Exercise... 

All serum Tipids, which consist of free cholesterol, glycerides, cholesterol ester and phospholipids, circulate in association with specific proteins (apo-lipoproteins) to form lipid-protein complexes. These macromolecular complexes are called "lipoproteins" and have remarkable hydrophilic properties, in spite of high lipid contents. Therefore, water insoluble lipids are transported from their organs for synthesis to their sites for utilization. Most serum lipoproteins have a molecular weight range from approximately 200,000 to 10,000,000 and contain from 40 % to 95 % of lipids. Studies of the factors affecting lipoprotein levels are very important for health and diseases, because lipoprotein levels are closely related to atherosclerosis and its clinical manifestations. 

Figure 7.9 shows the relationship between the concentration of cholesterol (section 4.3.1.3) in plasma, and specifically cholesterol in plasma low-density lipoproteins (LDL section 5.6.2.2), and premature death from ischaemic heart disease. The main dietary factor affecting the concentration of cholesterol in plasma is the intake of fat. 

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