Lipopolysaccharide receptor complex

CD13 CD14 CD 16/32 CD19 aminopeptidase N (metalloproteinase Zn-bound) LPS (lipopolysaccharide) receptor FcyRII/III (receptor II/III to Fey) B cell receptor co-receptor linked to PI-3 kinase forms complex ligands... 

Heine, H., El-Samalouti, V.T., Notzel, C., Pfeiffer, A., Lentschat, A., Kusumoto, S., Schmitz, G., Hamann, L., Ulmer, A.J. CD55/decay accelerating factor is part of the lipopolysaccharide-induced receptor complex. Eur J Immunol 33 (2003) 1399-1408. 

Lipopolysaccharide (EPS) LPS is a large molecule consisting of a lipid and a polysaccharide (carbohydrate). LPS acts as the prototypical endotoxin, because it binds the CD 14/TLR4/MD2 receptor complex, which promotes the secretion of proinflammatory cytokines in many cell types, but especially in macrophages. 

Autoimmune Disease. Figure 2 Generation of autoreactivity. APC, antigen presenting cell IFN, interferon LPS, lipopolysaccharide MHC, major histocompatibility complex T, T-lymphocyte TCR, Tcell (antigen) receptor TLR, toll like receptors. For details see text. 

Latz, E., Visintin, A., Lien, E., Fitzgerald, K.A., Monks, B.G., Kurt-Jones, E.A., Golenbock, D.T., Espevik, T. Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction. J Biol Chem 277 (2002) 47834-47843. 

Wright, S.D., Ramos, R.A., Tobias, P.S., Ulevitch, R.J., Mathison, J.C. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249 (1990) 1431-1433. Yang, H., Young, D.W., Gusovsky, F., Chow, J.C. Cellular events mediated by lipopolysaccharide-stimulated toll-like receptor 4. MD-2 is required for activation of mitogen-activated protein kinases and Elk-1. J Biol Chem 275 (2000) 20861-20866. 

Kawasaki, K. Akashi, S. Shimazu, R. Yoshida, T. Miyake, K. Nishijima, M. Mouse toll-like receptor 4-MD-2 complex mediates lipopolysaccharide-mimetic signal transduction by Taxol. J. Biol. Chem., 2000, 275 2251-2254. 

Akashi S, Shimazu R, Ogata H, Nagai Y, Takeda K, et al. 2000. Cutting edge cell surface expression and lipopolysaccharide signaling via the toll-like receptor 4-MD-2 complex on mouse peritoneal macrophages. J. Immunol. 164 3471-75... 

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