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Lipopolymers

Anwer K, Barnes MN, Fewell J, Lewis DH, Alvarez RD (2010) Phase-I clinical trial of IL-12 plasmid/lipopolymer complexes for the treatment of recurrent ovarian cancer. Gene Ther 17 360-369... [Pg.19]

Zalipsky S, Qazen M, Walker JA 2nd, Mullah N, Quinn YP, Huang SK (1999) New detachable poly(ethylene glycol) conjugates cysteine-cleavable lipopolymers regenerating natural phospholipid, diacyl phosphatidylethanolamine. Bioconjug Chem 10 703-707... [Pg.137]

Development of sterically stabilized liposomes (SSL) composed of high Tm lipids, cholesterol, and a lipopolymer, such as poly-(ethylene glycol methyl ether)-l,2-distearoyl-i n-glycero-3-phospho-ethanolamine triethyl ammonium salt (1,3-5,8,9,14,15)... [Pg.3]

Many types of liposomes of different lipid composition and different sizes having a transmembrane AS gradient were prepared (10). These liposomes varied (i) in their liposome-forming phosphatidylcholine (PC), being with and without cholesterol and/or lipopolymer (ii) in their size and (iii) in their method of preparation. The approaches for preparing these different liposome formulations varies in their lipid hydration and downsizing. Table 1 in Haran et al. (10) gives a partial list of such liposome preparations. In all cases the scheme of liposome preparation can be summarized as described in Table 4. [Pg.13]

Zhang J, et al. Pharmaco attributes of dioleoylphosphatidylethanolamine/ cholesterylhemisuccinate liposomes containing different types of cleavable lipopolymers. Pharmacol Res 2004 49 185. [Pg.291]

Mahato RI, Kim SW (2005) Water soluble lipopolymers for gene delivery. In Ammiji MM (ed) Polym Gene Deliv, CRC Press, Boca Raton... [Pg.143]

This approach was effective in that it expressed IL-4 pancreas specifically, without any side-effects from the systemic expression of IL-4. These results also indicated that autoim-mune diabetes in NOD mice is not a systemic disease, and it can be modulated from the islet compartment. Therefore, for somatic gene therapy, the rat insulin pro-moter was inserted upstream of the IL-4cDNA (Lee et al., 2001a). This plasmid, pRIP-mIL-4 was complexed with water soluble lipopolymer and transfected in vitro. The results indicated that pRIP-mIL-4 expressed IL-4 cell-type specifically. [Pg.474]

Lee, M., Han, S., Ko, K.S. and Kim, S.W. (2001a) Cell type specific and glucose responsive expression of interleukin-4 by using insulin promoter and water soluble lipopolymer. J. Control. Rel, 75, 421 129. [Pg.476]

This method is a combination of the other two methods. In our opinion, it is the most gentle method to reconstitute membrane proteins into supported bilayers and to prepare supported bilayers with fragile coexisting liquid phases of lipids. A LB monolayer is prepared on a hydrophilic substrate as described above. To prepare tethered-polymer supported bilayers, a suitable lipopolymer may be included at a concentration of a few... [Pg.2230]

Albertorio F, Diaz AJ, Yang T, Chapa VA, Kataoka S, Castellana ET, Cremer PS. Fluid and air-stable lipopolymer membranes for biosensor applications. Langmuir 2005 21 7476-7482. [Pg.2234]

C. Vermehren,T. Keibler, 1. Hylander, T. Hunger Callisen, and K. Jurgensen. Increase in phospholipase A2 activity towards lipopolymer containing liposomes. Biochim. Biophys. Acta, 1998, 1373, 27]-36. [Pg.52]

K. Jurgensen, C. Vermehren, and O.G. Mouritsen. Enhancement of phospholipase A2 catalyzed degradation of polymer grafted PEG-liposomes effects of lipopolymer concentration and chain length. Pharm. Res., 1999, 16, 1493-1495. [Pg.52]

Keywords Diffusion, Langmuir monolayer, Lipopolymer, Phospholipid, Viscoelasticity... [Pg.43]

Fig. 1 Commonly investigated lipopolymers and lipids l,2-distearoyl-in-glycero-3-phos-phatidylethanolamine-A-[poly(ethylene glycol ] (DSPE-PEG2000), 1,2-dioctadecanoyl-sn-glycero- [poly((2-methyl-2-oxazoline)r,)] (DiCi8PMOx30.5o). 1,2-dioctadecanoyl-sn-glycero-... Fig. 1 Commonly investigated lipopolymers and lipids l,2-distearoyl-in-glycero-3-phos-phatidylethanolamine-A-[poly(ethylene glycol ] (DSPE-PEG2000), 1,2-dioctadecanoyl-sn-glycero- [poly((2-methyl-2-oxazoline)r,)] (DiCi8PMOx30.5o). 1,2-dioctadecanoyl-sn-glycero-...
Fig. 4 Molecular structure of diblock copolymers and side-chain modified lipopolymers whose pressure-area isotherms are presented in Figs. 6 and 7, respectively. Diblock copolymers are poly(2-n-nonyl)-poly(2-methyl or 2-ethyl-2-oxazoline) (NxEy and NxMj,), where x and y denote the block sizes of the hydrophobic nonyl and hydrophilic oxazoline blocks. Side-chain modified lipopolymers, which contain short oligo-EG sidechains in each monomer of the lipopolymer to create a bottle-brush-like structure, are di-octadecanoyl-glycerol 2-(3 -methoxymonoethylene glycol)propyl-2-oxazoline (DiCigMEGOxn) and di-octadecanoyl-glycerol 2-(3 -methoxytiiethyleneglycol)propyl-2-oxazoline (DiCisTEGOxn) (adapted from [7,8])... Fig. 4 Molecular structure of diblock copolymers and side-chain modified lipopolymers whose pressure-area isotherms are presented in Figs. 6 and 7, respectively. Diblock copolymers are poly(2-n-nonyl)-poly(2-methyl or 2-ethyl-2-oxazoline) (NxEy and NxMj,), where x and y denote the block sizes of the hydrophobic nonyl and hydrophilic oxazoline blocks. Side-chain modified lipopolymers, which contain short oligo-EG sidechains in each monomer of the lipopolymer to create a bottle-brush-like structure, are di-octadecanoyl-glycerol 2-(3 -methoxymonoethylene glycol)propyl-2-oxazoline (DiCigMEGOxn) and di-octadecanoyl-glycerol 2-(3 -methoxytiiethyleneglycol)propyl-2-oxazoline (DiCisTEGOxn) (adapted from [7,8])...
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See also in sourсe #XX -- [ Pg.419 ]

See also in sourсe #XX -- [ Pg.43 , Pg.88 ]

See also in sourсe #XX -- [ Pg.178 ]



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Cationic Lipopolymers

Lipid-lipopolymer mixtures

Lipopolymer-phospholipid monolayer

Lipopolymers Langmuir monolayers

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