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Lipophobicity

Modification of the top electrode may also be achieved. This was done by adding a small amount of surfactant, such as an ether phosphate or an ether sulfate, to the spin-coal solution of the luminescent polymer [89[. The lipophobic ether chains segregate at the surface of the (predominantly) hydrocarbon polymer, becoming available for complexation with the aluminum cathode which is deposited on top. Thus, the dipole in the surfactant points away from the electrode and lowers its work function to improve the injection of electrons. [Pg.537]

Some agonists, such as methacholine, carbachol and bethanecol are structurally very similar to ACh (Fig. 6.6). They are all more resistant to attack by cholinesterase than ACh and so longer acting, especially the non-acetylated carbamyl derivatives carbachol and bethanecol. Carbachol retains both nicotinic and muscarinic effects but the presence of a methyl (CH3) group on the p carbon of choline, as in methacholine and bethanecol, restricts activity to muscarinic receptors. Being charged lipophobic compounds they do not enter the CNS but produce powerful peripheral parasympathetic effects which are occasionally used clinically, i.e. to stimulate the gut or bladder. [Pg.128]

Kaneko et al. (1993) have described a group of lipophilic ascorbic-acid analogues that have been studied in cultured human umbilical vein endothelial cells that were first incubated with test drug and then exposed to lipid hydroperoxides. Although ascorbate itself did not protect the endothelial cells, derivatives like CV3611 protected. Pretreatment was necessary. CV3611 was synergistic with vitamin E. The authors concluded that these lipophilic antioxidants incorporate into endothelial cell membranes where they are effective inhibitors of lipid peroxidation. In contrast, lipophobic antioxidants were not effective in their hands (Kaneko et al., 1993). [Pg.267]

Surfactants, sometimes called surface active agents or detergents, are amphiphilic materials which contain both apolar, hydrophobic (lipophilic) and polar, hydrophilic (lipophobic) groups (Hartley, 1948, 1977 Fendler and Fendler, 1975 Fendler, 1982 Lindman and Wennerstrom, 1980 Sudholter... [Pg.214]

Because of their high lipophobic character, compared with other ammonium salts, quaternary ammonium hydroxides are not readily prepared by liquidrliquid anion exchange. Only with quaternary ammonium hydrogen sulphates is it possible to transfer the ammonium hydroxide into the organic phase in any viable degree of concentration [30] and this procedure remains the cheapest and simplest procedure. Other methods include treatment of quaternary ammonium halides with silver oxide [31] and by anion exchange using polymer bound hydroxide [e.g. 32]. [Pg.4]

In summary, for the general population, the common routes of exposure to environmental compounds are ingestion, dermal contact and inhalation. Many PEAS are environmentally persistent but not lipophilic rather they have mixed lipophobic and hydrophobic properties. The exposure scenario is complex as PEAS have a large variety of applications. Gral exposure from materials other than food, inhalation and dermal contact may be important exposure routes for certain segments of the population. Dust inhalation could also be a possible source of exposure. However, the information on concentrations of PEAS in indoor dust is very limited and the bioavailability of the current compounds from dust is unknown. [Pg.367]

Mesogen composed of molecules consisting of two parts of contrasting character that are hydrophilic and hydrophobic or lipophobic and lipophilic. [Pg.97]

The word liposome comprises two terms (from Greek—lipid [fat] and soma [body]). It does not in itself denote any size characteristics. Furthermore, the term liposome does not necessarily mean that it must contain lipophobic contents, such as water, although it usually does. The vesicles may be conceived as microscopic (or nano-sized) containers of carrying molecules (drugs) from one place to another. The structures are suitable for both transporting water-soluble or water-insoluble drugs. Since the lipids used are biocompatible molecules, this may also enhance their adsorption and penetration into the cells. [Pg.102]

Absorption of some highly ionized compounds (e.g., sulfonic acids and quaternary ammonium compounds) from the gastrointestinal tract cannot be explained in terms of the transport mechanisms discussed earUer. These compounds are known to penetrate the Upid membrane despite their low Upid-water partition coefficients. It is postulated that these highly lipophobic drugs combine reversibly with such endogenous compounds as mucin in the gastrointestinal lumen, forming neutral ion pair complexes it is this neutral complex that penetrates the Upid membrane by passive diffusion. [Pg.24]

Detailed information, background reviews, or highlights from the authors about the specific properties of PFCs and fluorinated colloids in relation to biomedical applications can be found in Refs. [3-9]. These papers also provide insight into the surface properties of PFCs, their hydrophobic and lipophobic characters, self-aggregation properties, tendency to stabilize interfaces, and ability to promote nanocompartmentation in self-assembled systems. [Pg.448]

Fig. 16. Schematic representation of a fluorinated vesicle obtained from perfluoroalkylated phospholipids showing separated nanometer-thick domains within their bilayer membrane. The central hydrophobic and lipophobic fluorous core of the membrane is flanked by two lipophilic shells, then by the hydrophilic outermost and innermost layers of polar heads [4]. Fig. 16. Schematic representation of a fluorinated vesicle obtained from perfluoroalkylated phospholipids showing separated nanometer-thick domains within their bilayer membrane. The central hydrophobic and lipophobic fluorous core of the membrane is flanked by two lipophilic shells, then by the hydrophilic outermost and innermost layers of polar heads [4].
This is a lipophilic weak base (pKa 4), which crosses cell membranes easily at physiological pH. It is a prodrug, which at the acidic intracellular pH in the gastric parietal cell converts to the active sulfenamide form, which is lipophobic and so is trapped and preferentially concentrated in the parietal cells. Omeprazole is highly protein-bound. Hepatic metabolism is rapid, with a plasma half-life of 0.5-1.5 h, but because of covalent binding to the H-1-/K-1- ATPase enzyme, the duration of action exceeds 24 h. [Pg.186]

The biochemical structure of a membrane is that of a lipid bilayer composed of phospho- and sphingolipids, as well as cholesterol. These lipids are amphipathic in nature, that is, they each have a polar and a nonpolar end. In water the nonpolar (hydrophobic, lipophilic) ends will seek to avoid the polar solvent and aggregate into a bilayer with the polar (hydrophilic, lipophobic) ends oriented towards the outside of the bilayer. As this structure extends in all directions the exposed nonpolar regions will close up and form a sphere (or ellipsoid) with water trapped inside and excluded outside. See Figures 2a and 2b. [Pg.17]

Phenobarbital poisoning is exacerbated by its ionized forms also. Its pKa is about 7.2. At a urine pH of 7.4 there will exist about a 50 50 mixture of lipophilic and lipophobic species. Once again the uncharged form will be reabsorbed and the remaining barbiturate molecules will redistribute themselves according to the equilibrium eventually leading to the reabsorption of the virtually all of the phenobarbital. [Pg.57]

In both the cases presented alleviation of the toxic situation could be accomplished if the urine was made more alkaline in order to drive the ionization equilibria to the conjugate base forms which are lipophobic and therefore excretable in the urine. Bicarbonate can be administered in order to raise the pH and help in the elimination of the drugs. [Pg.57]

The reason for the experimentally proven lipophobicity, i.e., the tendency of fluorinated and hydrogenated chains to phase separate, is much less clear than the other effects of fluorination and is still under debate. Mostly it is assigned to the disparity of cohesive energy densities between perfluoroalkanes and alkanes. A reduction of ca. 10% in the interactions between unlike pairs of molecules was estimated by several methods [90]. However, there are also simulations suggesting slightly stronger attractive contributions to the interaction between Rf/Rh pairs compared to the like interactions under certain circumstances [94]. 9 However,... [Pg.14]

Besides the simple effects of mesophase stabilization by increased polar-apolar incompatibility and modification of mesophase morphology due to size effects, there are additional specific effects based on the lipophobicity (R[ -RH incompatibility) and rigidity of perfluorinated segments. In this respect it is important to... [Pg.31]

Recently it has been demonstrated by Guittard et al. that the electrochemical polymerization of semifluorinated thiophenes (226) [407], 3,4-ethylenediox-ythiophenes (227) [408], fluorenes [408], and 3,4-alkylenedioxypyrroles (230) [409] allowed the deposition of semiconducting polymer films with excellent antiwetting properties (superhydrophobic and lipophobic, see Fig. 73). Additional aromatics inserted between fluorinated tail and polymer chain (compounds 228, 231) improve mesogenity and in this way decrease the mobility of the Rp-chains, preorganize the molecules, and thus improve the antiwetting properties [388, 410]. [Pg.91]

Water solubility and vapor pressures of PFOS and PFOA are given in Table 2. These data were obtained from products that were not refined and as a result may contain more than one PFA such that these data may not be representative of the pure compounds, especially in environmental media. Due to the lack of accurate information on the physico-chemical properties, accurate prediction of the environmental fate and transport of most perfluoroalkyl substances has not yet been possible. The prediction of the distribution and ultimate fates of perfluoroalkyl substances is further complicated by their hydrophobic and lipophobic properties, such that the fugacity approach that has been useful in describing the environmental fates of organochlorines is less useful for describing the environmental fate of PFAs and their precursors. The bulk of the available physical and chemical information is for PFOS... [Pg.397]


See other pages where Lipophobicity is mentioned: [Pg.320]    [Pg.928]    [Pg.338]    [Pg.87]    [Pg.1]    [Pg.219]    [Pg.116]    [Pg.143]    [Pg.42]    [Pg.41]    [Pg.448]    [Pg.449]    [Pg.476]    [Pg.477]    [Pg.480]    [Pg.753]    [Pg.200]    [Pg.232]    [Pg.19]    [Pg.21]    [Pg.21]    [Pg.39]    [Pg.94]    [Pg.164]    [Pg.1583]    [Pg.75]    [Pg.14]    [Pg.15]    [Pg.96]    [Pg.57]    [Pg.190]   
See also in sourсe #XX -- [ Pg.31 ]

See also in sourсe #XX -- [ Pg.121 ]

See also in sourсe #XX -- [ Pg.151 ]




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Lipophilicity/lipophobicity

Lipophobe

Lipophobe

Lipophobic

Lipophobic

Lipophobic compounds

Surface active agents lipophobic group

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