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Lipophilic drug absorption lipid-based formulations

The ability of lipid vehicles (either in the pharmaceutical formulation or in food) to enhance the absorption of lipophilic drugs has been well known for many years. Recently, successful bioavailability enhancement utilizing lipid-based formulations has been accomplished with the immunosuppressive agent cyclosporine A (Neoral, Novartis Pharmaceuticals Corporation, East Hanover, NJ), and for the two HIV protease inhibitors ritonavir (Norvir, Abbott Laboratories, IL) and saquinavir (Fortovase, Roche Pharmaceuticals, Nutley, NJ). Consequently, considerable interest in lipid-based formulations has been aroused. [Pg.114]

The mechanisms by which lipid-based formulations enhance the absorption of lipophilic drugs are ... [Pg.114]

Dahan, A. and Hoffman, A. (2007) The effect of different lipid based formulations on the oral absorption of lipophilic drugs the ability of in vitro lipolysis and consecutive ex vivo intestinal permeability data to predict in vivo bioavailability in rats. European Journal of Pharmaceutics and Biopharmaceutics, 67 (1), 96. [Pg.50]

See other pages where Lipophilic drug absorption lipid-based formulations is mentioned: [Pg.245]    [Pg.122]    [Pg.228]    [Pg.237]    [Pg.115]    [Pg.124]    [Pg.110]    [Pg.126]    [Pg.1328]    [Pg.42]    [Pg.103]    [Pg.119]    [Pg.1382]    [Pg.120]    [Pg.125]    [Pg.43]    [Pg.818]    [Pg.653]    [Pg.818]    [Pg.340]    [Pg.625]    [Pg.243]    [Pg.677]   


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