Lipophilic conjugates novel

This review emphasizes recent examples of novel lipophilic conjugates. Previously reviewed nonpolar conjugates (1-3) are considered only briefly and although certain relatively simple conjugations (e.g. methylation, formylatlon, and acetylation) also... 

In search of novel natural antioxidant compounds that might posses a good brain bioavailability, our laboratory has focused attention on the phenolic compound ferulic acid ethyl ester (FAEE) (Fig. 18.1). Ferulic acid is a ubiquitous plant constituent that occurs primarily in seeds and leaves both in its free form and covalently linked to lignin and other biopolymers. Due to its phenolic nucleus and an extended side chain conjugation, it readily forms a resonance stabilized phenoxy radical that accounts for its potent antioxidant potential [Kanski et al., 2002 Kikuzaki et al., 2002], Ferulic acid has been shown to be protective against oxidative stress in vitro it is absorbed and excreted by humans, and may be a promising candidate for therapeutic intervention in AD [Yan et al., 2001]. Although ferulic acid has been demonstrated to be effective in vitro, the low lipophilicity impairs its in vivo efficiency, bioavailability, and stability. 

Similarly, in other mouse tissues and also in rat tissues, the presence of CPIA-cholesterol ester was demonstrated following administration of the Ba isomer or fenvalerate. Thus, CPIA-cholesterol ester proves now to be a novel type of conjugate which is more lipophilic than the parent compound and CPIA. 

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