Lipogenesis, epidermal

It has been reported also that epidermal growth factor stimulates fatty acid synthesis and the phosphorylation of ACC in rat liver and adipose tissues (Holland and Hardie, 1985) through phosphorylation of the I-peptide, suggesting that several peptide hormones sharing homology with insulin, such as IGF-1, could enhance lipogenesis similarly. 

Epidermal sterol biosynthesis in ichthyosis vulgaris was studied by Summerly and Yardley , who found that acetate incorporation into sterols was increased (but not significantly so). These results were weight-corrected, and so may have been distorted by the presence of inert scale in the ichthyotic samples. We therefore decided to reinvestigate sterol biosynthesis in ichthyosis, within the context of total epidermal lipogenesis. 

Table 3.1 Epidermal lipogenesis from [ Cjglucose in ichthysosis vulgaris...

Dykes, P. J. and Marks, R. (1977). Epidermal lipogenesis and macromolecular synthesis in autosomal dominant ichthyosis and the acquired ichthyosis associated with disorders of the small bowel. (Presented at the annual meeting of the European Society for Dermatological Research, May 2-4, Amsterdam)... 

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