Lipinski, Christopher

Lipinski, Christopher A., Pfizer Global Research and Development, Mail Stop 8118W/220, Eastern Point Road, Groton, Connecticut 06340/0177, USA... [Pg.778]

In 1997, Christopher Lipinski of Pfizer reported simple criteria for predicting whether a drug can readily cross membranes by passive diffusion.13 Lipinski s criteria are known as Lipinski s rules or the Rule of Five (Table 3.7) and are based on a compound s molecular weight, lipophilicity, and number of hydrogen bond donors and acceptors. [Pg.51]

Chapter 10. Agents Affecting Gastrointestinal Functions Christopher A. Lipinski and Lyle A. Hohnke, Pfizer Inc., Groton, Conn. 06340... [Pg.91]

Christopher A. Lipinski and Nancy J. Hutson Pfizer Central Research, Groton, CT 063[Pg.169]

Christopher A. Lipinski, Ph.D, Pfizer Global R D, Groton Labs, Eastern Point Road, MS 8200-36, Groton, CT 06340, E-mail christopher a lipinski groton.pfizer.com... [Pg.482]

The terms druggability and drug-likeness were first introduced by Dr. Christopher Lipinski, who proposed Lipinski s rule of 5 due to the frequent appearance of a number 5 in the rules (Lipinski, 20(X)). The rule of 5 has come to be a compass for the drug discovery industry (Lipinski et al 2(X)1). It stipulates that small-molecule drug candidates should possess ... [Pg.83]

Tudor I Oprea, Cristian G Bologa, Scott Boyer, Ramona F Curpan, Robert C Glen, Andrew L Hopkins, Christopher A Lipinski, Garland R Marshall, Yvonne C Martin, Liliana Ostopovici-Halip, Gilbert Rishton, Oleg Ursu, Roy J Vaz, Chris Waller, Herbert Waldmann Larry A Sklar... [Pg.3]

Christopher A Lipinski, Garland R Marshall, Yvonne C Martin, Liliana Ostopovici-Halip, Gilbert Rishton,... [Pg.14]

Tudor I Opi-ea, Cristian G Bologa, Scott Boyer, Ramona F Curpan, Robert C Glen, Andrew L Hopkins, Christopher A Lipinski,... [Pg.21]

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