Lipidomics lipid rafts

Early descriptions of lipid rafts noted their enrichment in cholesterol and glycosph-ingolipids and focused on their ability to resist extraction by nonionic detergents [32]. Later experiments showed that lipid rafts were a heterogeneous collection of domains that differ in protein and lipid composition as well as in temporal stability [33, 34]. The distinctive lipid composition of membrane rafts as demonstrated by lipidomics makes a clearer picture of membrane rafts. 

Rappley I, Myers DS, Milne SB, et al. Lipidomic profiling in mouse brain reveals differences between ages and genders, with smaller changes associated with alpha-synuclein genotype. /Neumchem. 2009 lll(l) 15-25. Fantini J, Garmy N, Mahfoud RS, Yahi N. Lipid rafts structure, function and role in HIV, Alzheimer s and prion diseases. Exp Rev Mol Med. 2002 4(27) l-22. 

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