Lipid - regulating drugs fibrates

Rhabdomyolysis is the destruction of skeletal muscle tissues and may be associated with lipid-regulating drugs such as the fibrates and the statins. The risk of this side-effect is increased in patients with renal impairment and with hypothyroidism. Rhabdomyolysis may also occur with nicotinic acid, the antipsychotic aripiprazole, and the anaesthetic propofol. 

Fibrate drugs are a class of lipid regulatory drugs. They are used to regulate blood lipid and cholesterol levels. They include drugs such as gemfibrozil, ciprofibrate, clofibrate, bezafibrate and fenofibrate (Fig. 1). As noted in Table 1, gemfibrozil (GEM) was identified in /xg/l concentrations in post-STP effluents collected from... 

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