Lipid hydroperoxides decomposition products, toxicity

The Toxicity of Lipid Hydroperoxides and Their Decomposition Products... 

Firstly, I will discuss recent evidence supporting the hypothesis that free radicals contribute to important chronic diseases in man and exert an important life-shortening effect. Secondly, I will review data on the toxicity of lipid hydroperoxides and their decomposition products, since lipid hydroperoxides can be a source of free radicals in vivo. And lastly, I will review a system under study in our laboratory in which quantitative data on lipid peroxidation and antioxidants is being obtained using linoleic acid in SDS micelles. 

Numerous studies have confirmed that lipid hydroperoxides are toxic, their products of decomposition even more so. For example, loss of -OH by cleavage of the relatively weak 0-0 bond gives rise to an alkoxy radical, which may decompose by breaking a neighboring C-C bond (j8-scission), forming an unsaturated aldehyde. 

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