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Lipid homeostasis, PPARa regulation

Since the rodent effects of PPs ate mediated via PPARa and humans appear to be non-responsive to these adverse effects, species differences in PPARa expression levels provide a plausible explanation for the lack of hitman response. However, humans do respond to PPs by altering etqtression of enzymes that regulate serum cholesterol and lipid homeostasis. " In addition, human liver does contain a functional PPARa although the expression of PPARa in humans is around 10-fold lower when compared with responsive species such as rat and mouse."" "" In total, these data support a quantitative hypothesis whereby PPARa expression in humans is sufficient to mediate the beneficial effects of hypolipidaemic dmgs via regulation of genes for enzymes and lipid transporters. [Pg.543]

See other pages where Lipid homeostasis, PPARa regulation is mentioned: [Pg.262]    [Pg.304]    [Pg.635]    [Pg.445]    [Pg.87]    [Pg.194]    [Pg.286]    [Pg.211]    [Pg.219]    [Pg.803]    [Pg.30]    [Pg.211]    [Pg.219]    [Pg.109]    [Pg.167]    [Pg.285]    [Pg.218]   
See also in sourсe #XX -- [ Pg.445 ]



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