Lipid-based drug delivery systems liposomes

FIGURE 10.3 Schematic presentation of lipid based drug delivery systems. Micelles (right) are composed of a solid lipid core with the polar heads exposed to the aqueous environment. Liposomes (left) are particles with a hpid bilayer surrounding an aqueous core. Drug can be encapsulated in the hydrophobic regions of the lipid particle, in the aqueous environment of the liposome, or adsorbed to the surface of the lipid particle. 

Zarif, L. Graybill, D. Berlin, R. Mannino, R.J. Cochleates new lipid-based drug delivery system. J. Liposome Res. 2000,10 (4), 523-538. 

DepoDur is a sterile, non-pyrogenic, white to olf-white, preservative-free suspension of multi-vesicular lipid-based particles containing morphine sulfate, USP. The lipid carrier is a proprietary drug delivery system known as DepoFoam . After the administration of DepoDur into the epidural space, morphine sulfate is released from the multivesicular liposomes over a period of time [1-3] (Figures 44.2 and 44.3). 

In the wake of the commercial success of several liposome dmg products, lipid-based carriers are on the verge of becoming an accepted and versatile tool in drug delivery. Porter and Charman (Chapter 4) add an entirely new dimension to the usefulness of lipid-based carriers by showing that the systemic distribution... 

Liposomes are phospholipid-based vesicles which have been studied as delivery systems to target drugs to specific sites in the body. " The surface of a liposome can be neutral or negatively or positively charged, depending on the composition of lipids used. For... 

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